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排序方式: 共有1144条查询结果,搜索用时 15 毫秒
21.
In this paper we derive the asymptotic behaviour of the survival function of both random sum and random maximum of log-normal risks. As for the case of finite sum and maximum investigated in Asmussen and Rojas-Nandayapa (2008) also for the more general setup of random sums and random maximum the principle of a single big jump holds. We investigate both the log-normal sequences and some related dependence structures motivated by stationary Gaussian sequences. 相似文献
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Cannibalization is a major concern for a firm when designing a product line. In addition, external options from outside the firm’s product line may also play a significant role. In this paper, we investigate the impact of external options, represented by reservation utility, on product line design and introduction sequence. We find that: (a) heterogeneous reservation utility defines the relative attractiveness of segments and corresponding product line; (b) reservation utility makes it more favorable to introduce products sequentially rather than simultaneously; (c) aggregating segments is an effective way to mitigate cannibalization when it becomes too difficult to manage with different values of reservation utility across multiple segments; and (d) introducing products in a non-monotone order of quality can improve profit from simultaneous introduction when the value of reservation utility of a middle segment is particularly high. 相似文献
24.
Restraint of the Differentiation of Mesenchymal Stem Cells by a Nonfouling Zwitterionic Hydrogel 下载免费PDF全文
Tao Bai Fang Sun Lei Zhang Andrew Sinclair Sijun Liu Jean‐Rene Ella‐Menye Ying Zheng Prof. Shaoyi Jiang 《Angewandte Chemie (International ed. in English)》2014,53(47):12729-12734
The success of human mesenchymal stem cell (hMSC) therapies is largely dependent on the ability to maintain the multipotency of cells and control their differentiation. External biochemical and biophysical cues can readily trigger hMSCs to spontaneously differentiate, thus resulting in a rapid decrease in the multipotent cell population and compromising their regenerative capacity. Herein, we demonstrate that nonfouling hydrogels composed of pure poly(carboxybetaine) (PCB) enable hMSCs to retain their stem‐cell phenotype and multipotency, independent of differentiation‐promoting media, cytoskeletal‐manipulation agents, and the stiffness of the hydrogel matrix. Moreover, encapsulated hMSCs can be specifically induced to differentiate down osteogenic or adipogenic pathways by controlling the content of fouling moieties in the PCB hydrogel. This study examines the critical role of nonspecific interactions in stem‐cell differentiation and highlights the importance of materials chemistry in maintaining stem‐cell multipotency and controlling differentiation. 相似文献
25.
Mohammad Noh Daud 《化学物理学报》2011,24(6):679-685
采用时间依赖的量子波包法研究14N14N16O、14N15N16O、15N14N16O、15N15N16O、14N14N17O和14N14相似文献
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Let ψ be a holomorphic function on the open unit disk D and φ a holomorphic self-map of D. Let Cφ,Mψ and D denote the composition, multiplication and differentiation operator, respectively. We find an asymptotic expression for the essential norm of products of these operators on weighted Bergman spaces on the unit disk. This paper is a continuation of our recent paper concerning the boundedness of these operators on weighted Bergman spaces. 相似文献
28.
Quality function deployment (QFD) is a useful analyzing tool in product design and development. To solve the uncertainty or imprecision in QFD, numerous researchers have applied the fuzzy set theory to QFD and developed various fuzzy QFD models. Three issues are investigated by examining their models. First, the extant studies focused on identifying important engineering characteristics and seldom explored the subsequent prototype product selection issue. Secondly, the previous studies usually use fuzzy number algebraic operations to calculate the fuzzy sets in QFD. This approach may cause a great deviation in the result from the correct value. Thirdly, few studies have paid attention to the competitive analysis in QFD. However, it can provide product developers with a large amount of valuable information. Aimed at these three issues, this study integrates fuzzy QFD and the prototype product selection model to develop a product design and selection (PDS) approach. In fuzzy QFD, the α-cut operation is adopted to calculate the fuzzy set of each component. Competitive analysis and the correlations among engineering characteristics are also considered. In prototype product selection, engineering characteristics and the factors involved in product development are considered. A fuzzy multi-criteria decision making (MCDM) approach is proposed to select the best prototype product. A case study is given to illustrate the research steps for the proposed PDS method. The proposed method provides product developers with more useful information and precise analysis results. Thus, the PDS method can serve as a helpful decision-aid tool in product design. 相似文献
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Abstract The enhanced osteoblast differentiation is beneficial to the prevention of osteoporosis. In this study, a homogeneous polysaccharide (LRP-S2A) with the potential of promoting osteoblast differentiation was obtained from the fruits of Lycium ruthenicum, a traditional herb for treatment of postmenopausal metabolic disorders. Structural identification indicated that LRP-S2A, with a relative molecular weight of 2.65 × 106 Da and an uronic acid content of 41.8%, contained Rha, Ara, Gal, Glc and GlcA in a molar ratio of 1.00 : 2.07 : 0.57 : 2.59 : 4.33 and was composed of a backbone consisting of 6-O-Me-α-(1→4)-D-GlcpA, 2-O-acetyl-α-(1→4)-D-Glcp, α-(1→2,4)-L-Rhap, β-(1→3)-D-Galp andα-(1→3,5)-L-Araf, and some branches consisting of 6-O-Me-α-(1→4)-D-GlcpA and terminal α-L-Araf. These results suggested that LRP-S2A with the potential of promoting osteoblast differentiation was a new acidic polysaccharide. 相似文献
30.
Liesbeth Tytgat Matthias R. Kollert Lana Van Damme Hugo Thienpont Heidi Ottevaere Georg N. Duda Sven Geissler Peter Dubruel Sandra Van Vlierberghe Taimoor H. Qazi 《Macromolecular bioscience》2020,20(4)
Adipose tissue engineering aims to provide solutions to patients who require tissue reconstruction following mastectomies or other soft tissue trauma. Mesenchymal stromal cells (MSCs) robustly differentiate into the adipogenic lineage and are attractive candidates for adipose tissue engineering. This work investigates whether pore size modulates adipogenic differentiation of MSCs toward identifying optimal scaffold pore size and whether pore size modulates spatial infiltration of adipogenically differentiated cells. To assess this, extrusion‐based 3D printing is used to fabricate photo‐crosslinkable gelatin‐based scaffolds with pore sizes in the range of 200–600 µm. The adipogenic differentiation of MSCs seeded onto these scaffolds is evaluated and robust lipid droplet formation is observed across all scaffold groups as early as after day 6 of culture. Expression of adipogenic genes on scaffolds increases significantly over time, compared to TCP controls. Furthermore, it is found that the spatial distribution of cells is dependent on the scaffold pore size, with larger pores leading to a more uniform spatial distribution of adipogenically differentiated cells. Overall, these data provide first insights into the role of scaffold pore size on MSC‐based adipogenic differentiation and contribute toward the rational design of biomaterials for adipose tissue engineering in 3D volumetric spaces. 相似文献